Genital endometriosis (GE) remains a significantly common disease, occurring in 0.5-5% of fertile women and in 25-40% of women with infertility. In patients with GE, there is a decrease in apoptosis in endometrial cells compared to healthy women, even more pronounced in ectopic foci, as a result of which their proliferative activity increases and the ability to abnormal implantation increases. The use of immune peptides in endometriosis, which are capable of activating regulatory macrophages and stimulating the recruitment of T-lymphocytes, opens up new possibilities for controlling the disease. Arecur, which contains immune peptides, including defensins and RJP-1, tunes immune cells to maximize their productivity against ectopic tissue, potentially creating conditions for the prevention of endometriosis-associated ovarian cancer. The use of immune peptides in endometriosis quite predictably contributes to more efficient work of local immunity. Immune cells potentiated with peptides not only independently attack and separate the intercellular connections in the endometrioma, but also provoke apoptosis of ectopic cells. The use of immune peptides in endometriosis opens up new prospects for increasing the effectiveness of treatment and prevention of this disease.

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